{"id":720,"date":"2020-07-16T16:36:57","date_gmt":"2020-07-16T16:36:57","guid":{"rendered":"https:\/\/biocore.es\/?page_id=720"},"modified":"2020-08-12T14:13:53","modified_gmt":"2020-08-12T14:13:53","slug":"microbioma-e-inmunidad","status":"publish","type":"page","link":"https:\/\/biocore.es\/?page_id=720","title":{"rendered":"Microbioma"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"720\" class=\"elementor elementor-720\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-55bf666 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"55bf666\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9b3ffee\" data-id=\"9b3ffee\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c1c98a elementor-widget elementor-widget-heading\" data-id=\"9c1c98a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">&lt;p<\/p>Microbioma e inmunidad<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6bdd42a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6bdd42a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-5f30821\" data-id=\"5f30821\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d50f09b elementor-widget elementor-widget-image\" data-id=\"d50f09b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/biocore.es\/wp-content\/uploads\/elementor\/thumbs\/SS2733656-e1594922313154-ovk0zw1tmy5w2kqeonydsyhut5kdboq5xdremt2c28.jpg\" title=\"SS2733656\" alt=\"SS2733656\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-43d16ee\" data-id=\"43d16ee\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-279ded1 elementor-widget elementor-widget-text-editor\" data-id=\"279ded1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Se busca estudiar c\u00f3mo los cambios en la <b>microbiota<\/b> afectan en la actividad y la transformaci\u00f3n morfofuncional de los neutr\u00f3filos en circulaci\u00f3n (activaci\u00f3n y envejecimiento celular), en proporci\u00f3n y cantidad, as\u00ed como el impacto que tiene el envejecimiento (general del animal) en este proceso.<\/p>\n<p>Los <b>neutr\u00f3filos<\/b> son una pieza clave del sistema inmune innato, fundamentales en la interacci\u00f3n del cuerpo con microorganismos simbiontes y agentes potencialmente infecciosos. Es sabido que, por otro lado, son componentes importantes en algunos cuadros patol\u00f3gicos relacionados con la senescencia (c\u00e1ncer, enfermedades degenerativas y autoinmunes), siendo esta una faceta relacionada con cuadros pro-inflamatorios en general. Tal como ocurre con otras c\u00e9lulas del sistema inmune, la activaci\u00f3n de los neutr\u00f3filos y otros procesos de regulaci\u00f3n est\u00e1n relacionados con la flora microbiana o microbiota intestinal.<\/p>\n<p>Partimos de la hip\u00f3teisis (respaldada por la bibliograf\u00eda) de que la microbiota en general tiene un papel importante en c\u00f3mo se desenvuelven los neutr\u00f3filos, para plantear un dise\u00f1o experimental que persigue determinar si algunas combinaciones de probi\u00f3ticos pueden ser de ayuda para regular la actividad y destino de los neutr\u00f3filos, y observar qu\u00e9 impacto tiene esto en organismos envejecidos.<\/p>\n<p>Esta investigaci\u00f3n puede ser \u00fatil en la b\u00fasqueda de tratamientos complementarios y protocolos m\u00e9dicos en cuadros relacionados de alg\u00fan modo a la actividad pro-inflamatoria de algunas subpoblaciones neutr\u00f3filos, y de la senescencia en general como marco com\u00fan de muchas de estas enfermedades.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page_front-page.php","meta":{"footnotes":""},"class_list":["post-720","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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